Ferguson made seven changes for the 2-2 draw with Yeovil on Monday to rest some tired legs but is likely to bring the likes of Craig Mackail-Smith, George Boyd, Joe Lewis, Grant McCann and Ryan Bennett back into the side.
Posh have already booked their place in the play-offs but will be looking for two more wins to secure home advantage in the second leg.
Right-back Mark Little is out with his ankle problem and left-back Grant Basey is likely to be missing for a couple of weeks with a knee injury.
Former Dale full-back Tom Kennedy only has a slight chance of being involved in the play-offs after damaging his knee ligaments in the recent win at Dagenham.
Source: PA
Source: PA