Little was sent-off during the 2-2 draw at Bristol Rovers last week and serves a one-match suspension, so Kelvin Langmead or Chris Whelpdale are likely to fill in.
Captain Grant McCann is available after international duty with Northern Ireland while top scorer Craig Mackail-Smith is fine to start after he made his Scotland debut against Brazil on Sunday.
Centre-back Ryan Bennett should be back from an ankle injury but midfielder Lee Frecklington has had a hernia operation and will be sidelined for several more weeks.
Striker Dave Hibbert is absent as he steps up his comeback from a dislocated knee suffered back in November.
Source: PA
Source: PA