The DR Congo international dislocated his shoulder in the midweek defeat of Brentford and could be out for as long as two months.
That should see Kelvin Langmead return to the starting line-up as Ferguson looks for a winning start back at the helm.
Loan signings Kieran Agard and Jonathan Obika will both be on the bench after Obika came on to score the winner in midweek while Joe Lewis will start in goal.
The England Under-21 international has handed in a transfer request at London Road after setting his sights on a move to the top flight but the club are yet to receive a suitable offer so he will play on.
Midfielder Charlie Lee - a staple of the side in Ferguson`s first spell - is battling an ankle injury but could return while Lee Frecklington is now fit after an ankle injury.
Source: PA
Source: PA